Cell-selective deletion of brain AT1A receptors in hypertension: Effect on blood pressure, increased ROS production and inflammation.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1029396

Funding Status
Closed

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Funded Activity Summary

Angiotensin is important for normal regulation of blood pressure but is also involved in cardiovascular diseases. Interruption of angiotensin’s actions is a common treatment of these diseases. Functional deletion of angiotensin receptors decreases blood pressure. Surprisingly the site(s) in the body responsible for this decrease are not known. We will examine the role of angiotensin receptors in the brain in the control of blood pressure in health and in cardiovascular disease.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $578,268.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Autonomic Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cre/lox knockout mice | baroreceptor reflexes | blood pressure regulation | hypertension | lentivirus | sympathetic nervous system | transgenic mouse

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