How does genetic variation for Trig affect autoimmune responses mediated by toll-like receptors?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1029231

Funding Status
Closed

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Funded Activity Summary

Juvenile diabetes is an autoimmune disease that affects more than 120,000 Australians. We have recently discovered a novel gene, named Trig, in a genetic study of mice that develop juvenile diabetes similar to children. This research proposal aims to determine the function of Trig in the immune system and how it contributes to the development of autoimmune diseases, such as juvenile diabetes.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $671,114.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Autoimmunity

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Toll-like receptors | autoimmune disease | congenic strains | cytokine regulation | dendritic cell | diabetes | immune tolerance | knockout mouse | susceptibility genes

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