Strategies to achieve kidney transplant tolerance in a clinically-relevant model

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1029205

Funding Status
Closed

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Funded Activity Summary

The acceptance of kidney transplants without immunosuppression (tolerance) would avoid the side effects of these powerful drugs and improve long-term graft survival. Donor brain death causes inflammation in transplanted kidneys which can block tolerance. In this project, we aim to determine whether expression of a naturally-occurring soluble anti-inflammatory molecule in the liver can prevent this inflammation, allowing tolerance to develop.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $663,490.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nephrology and Urology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

gene transfer | innate immunity | ischaemia/reperfusion | kidney transplantation | organ donation | transplantation tolerance

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