Can Blockade of Leptin Action in the Brain reduce Blood Pressure in Obese Mice?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1029188

Funding Status
Closed

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Funded Activity Summary

The aim of these studies is to determine if high leptin levels in obese mammals activate the sympathetic nervous system (SNS), and thereby contribute to pathologically high blood pressure, increased heart rate and diabetes. If so, it may be possible to develop novel therapeutics to acutely improve a patient's metabolic condition, by blocking leptin action. The obese are already insensitive to the anorectic actions of leptin, so blocking leptin would likely have no deleterious consequences.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $653,049.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

hypertension | leptin | neuropeptide Y (NPY) | obesity | pro-opiomelanocortin (POMC)

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