Investigation of a New Leukocyte Recruitment Mechanism at Sites of Vascular Injury

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1028564

Funding Status
Closed

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Funded Activity Summary

Blood clots formed at sites of small vessel injury can cause damage of vital organs by obstructing blood flow and promoting a proinflammatory response by efficiently recruiting and activating leukocytes. The molecular mechanisms responsible for the latter event are poorly defined. We have established a new mouse model, gained novel insights into the leukocyte recruitment by blood clots, and aim to define the precise mechanism for this process in this application.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $547,216.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

adhesion mechanisms | inflammation | platelets | thrombosis | vascular biology

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