Microparticles are pathogenic elements in the pathophysiology of cerebral malaria

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1028241

Funding Status
Closed

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Funded Activity Summary

Cerebral malaria (CM) is still a world health problem. We aim to better understand its mechanisms by deciphering the role of small blood elements called microparticles (MP). We discovered elevated numbers of MP in CM patients and demonstrated that preventing MP overproduction in mice protects against this fatal disease. Our research will investigate the mechanisms of action and the fate of MP in the blood vessels during CM and allow us to identify strategies for patientÍs treatment and care.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $605,205.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cerebral malaria | endothelial function | inflammation | pathogenesis | platelets

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