Role of islet ?-cell failure in the pathogenesis of non-alcoholic steatohepatitis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1028108

Funding Status
Closed

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Funded Activity Summary

Some people respond to obesity poorly developing diseases such as non-alcoholic steatohepatitis (NASH) and diabetes. Other people do not, safely storing the excess energy in non-abdominal fat. The applicants will study 2 obese strains of mice; one develops “adipose tissue restriction”, NASH and diabetes, the other does not. The hypothesis that failure of compensatory insulin secretion to over-nutrition is an upstream event causing adipose tissue restriction, followed by NASH, will be tested.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $560,111.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Endocrinology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

adipose tissue | diabetes mellitus | fatty liver disease | insulin resistance | insulin secretion | obesity | pancreatic islets

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