Immunoglobulin germline genes, BCR repertoire development and disease susceptibility. An investigation of haplotypic variation between individuals

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1027926

Funding Status
Closed

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Funded Activity Summary

The immune system is capable of making a repertoire of protective antibodies including literally tens of millions of different specificities. These are produced by permutations and combinations of a small set of ‘germline’ genes. This project will analyse how individual variations in the germline genes lead to individual differences in the repertoires of available antibodies, and will investigate whether or not such differences contribute to our susceptibility to infection and autoimmune diseases.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $519,828.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Immunogenetics (incl. Genetic Immunology)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

immunocompetence | immunogenetics | immunoglobulin (Ig) | immunopathology | population genetics | recombination | somatic mutation

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