The role of scube gene function in hedgehog signal transduction

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1027862

Funding Status
Closed

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Funded Activity Summary

The Hedgehog signaling pathway controls development of the early embryo and is one of the most common pathways mutated in human cancer. Through the use of zebrafish genetics we have identified a new component of this pathway, Scube2 that controls the ability of cells to be activated by Hedgehog signaling. We plan to further investigate how this occurs and design therapeutically relevant peptides based on the scube2 protein that could act as inhibitors of the pathway

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $547,216.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental Genetics (incl. Sex Determination)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer cell biology | developmental genetics | muscle development | signalling pathways | zebrafish

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