NDI1 Therapy for NADH-Ubiquinone Oxidoreductase Deficiency

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1027813

Funding Status
Closed

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Funded Activity Summary

This study will test a new protein therapy that can act as a surrogate for a deficient or defective enzyme called Mitochondrial Complex 1. The deficiency occurs in newborns with defective genes for the proteins that form the enzyme. The defect causes metabolic malfunction in most organs, with patients needing specialist hospital and parental care, but there is no cure yet. We have successfully tested this in the lab but will now test this in our new animal model of the disease.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $575,762.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

congenital disorders | electron transport | mitochondrial disease | paediatric | transgenic mouse

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