Probing central and peripheral calcium channel sybtypes with novel omega conotoxins

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/102585

Funding Status
Closed

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Funded Activity Summary

New toxins including omega-conotoxin CVID have been discovered from fish eating cone snails found on the Great Barrier Reef. These toxins discriminate between ion channel receptors on nerve cells that allow calcium ions to enter the cell and nerve transmission to continue. Of great importance is the fact that CVID specifically and potently blocks nerves that transmit pain responses. This project is involved with understanding the nolecular basis for this action with the goal of underpinning the design of even more selective agents that will ameliorate pain while reducing side effects.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $383,168.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

calcium channels | electrophysiology | neurotransmission | omega conotoxins | pain | peptide synthesis | stroke therapy | structure-function activity

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