The role of beta-Amyloid Precursor Protein and Tau in the regulation of neuronal iron

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1025774

Funding Status
Closed

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Funded Activity Summary

We have recently discovered a novel relationship between amyloid precursor protein (APP) and tau in regulating neuronal iron balance. This project will establish how tau aids APP transport to the cell surface where it assists cellular iron release. A commonality in some neurodegenerative diseases are disruptions in either proteinsÍ function and iron-related excitotoxicity. Understanding the iron role of APP and tau will lead to a therapeutic mechanism of action and better future drug design.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $650,226.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurology and Neuromuscular Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | Parkinson disease | amyloid precursor protein | animal model | disease mechanisms | drug targeting | frontotemporal dementia | iron overload | iron transport | microtubule associated protein (MAP)

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