Mapping the TNF Pathway: A qualitative and quantative molecular analysis of the components and post-translational modifications involved in physiological and pathological TNFR1 signalling

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1025594

Funding Status
Closed

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Funded Activity Summary

TNF is a master regulator of the inflammation response and dysregulated TNF signalling causes many human diseases. We will use a cutting edge mass spectrometry technique that we have developed to analyse molecules required for TNF signalling. Understanding how the TNF signalling works in all cell types and with different forms of ligands will open up therapeutic opportunities to selectively target TNF signalling in inflammatory diseases, such as Rheumatoid Arthritis and Cancer.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $636,258.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

apoptosis | cell death | necrosis | signal transduction | transcription factor | tumour necrosis factor (TNF) | ubiquitination

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