The role of intracellular protein trafficking in Alzheimer's disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1025538

Funding Status
Closed

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Funded Activity Summary

Alzheimer’s disease (AD) is a progressive neurological disorder and is the most common cause of dementia. The development of therapies must be preceded by a thorough understanding of the molecular processes that underpin the disease. In this project we will examine the interactions between the Alzheimer’s precursor protein (APP) and the molecular machinery that controls its intracellular localization and breakdown to the toxic A? peptide that is central to disease pathology.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2013

Funding Scheme: Project Grants

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Trafficking

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | X-ray crystallography | amyloid precursor protein | endosomes | membrane trafficking | neurodegenerative disorders | protein trafficking | protein-protein interaction | structure-function

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