Manipulating store-operated Ca2+ entry to improve muscle function in dystrophy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1025355

Funding Status
Closed

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Funded Activity Summary

Muscle function is regulated in a complex manner by calcium and is impaired in Duchenne muscular dystrophy (DMD). Changes in calcium regulation will be investigated in DMD patients and in an animal model using a novel approach. We will use a combination of novel experimental approaches to manipulate muscles in dystrophic mice and test for improvement in function. Results will determine the viability of a potential treatment.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $516,163.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Physiology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

calcium imaging | dystrophy | excitation-contraction coupling | muscle disease | muscle function | muscular dystrophy | peripheral nervous system (PNS) | skeletal muscle

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