A New Class of Anti-Malarial Agents Targetting Apical Membrane Antigen

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1025150

Funding Status
Closed

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Funded Activity Summary

Malaria is a major global health problem that imposes a substantial burden on the world’s most vulnerable societies. The invasion of host cells by malaria parasites represents an attractive target for therapeutic intervention, and Apical Membrane Antigen 1 (AMA1) plays an essential role in this process. Agents that bind to a key interaction site on AMA1 prevent host cell invasion and thus represent starting points for the development of a new class of anti-malarial drugs.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $597,598.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

X-ray crystallography | biophysics | drug development | drug discovery | malaria therapy | medicinal chemistry | nuclear magnetic resonance (NMR) spectroscopy | structure-based drug design

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