Dendritic cell function, migration and modulation in a murine model of inflammatory arthritis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/102513

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Rheumatoid arthritis (RA) is a debilitating disease that affects the joints and other tissues. While it can often be controlled with drugs, complete remission off treatment is rare. Dendritic cells are the educators of the immune system. By displaying antigen to T cells they communicate the response that the immune system should make to foreign organisms, tumors and to self. Therefore, a communication failure may result in chronic inflammation, tumor growth or autoimmune disease, such as RA. In this proposal, we focus on the role of dendritic cells in a mouse model of RA and explore ways of using dendritic cells to turn off disease, that if successful may translate in humans to induction of remission.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $201,870.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical chemistry (incl. diagnostics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antigen induced arthritis | bone marrow chimera | chemotaxis and migration | dendritic cells | inflammatory disease | rheumatoid arthritis | vaccination immunology

Related Links