Studies on the flavivirus nonstructural proteins and untranslated regions of the genome involved in virus replication

Funded Activity Summary

Flaviviruses cause potentially fatal diseases of global importance such as yellow fever, Japanese encephalitis (JE) and dengue haemorrhagic fever. Flavivirus disease is also important in Australia with recurrent outbreaks of dengue fever, Australian encephalitis and more recently JE in the northern regions of the continent. Effective vaccines are only available to yellow fever and JE and tick-borne encephalitis and are either live or killed preparations which are potentially hazardous and costly to produce. There are no therapeutic agents (antivirals) available against flavivirus diseases. To produce safe and cost effective vaccines against flaviviruses and to identify targets for antiviral agents, a more complete understanding of how these viruses replicate in the cell and cause disease is required. This investigation aims to define specific aspects of the flavivirus life cycle that are currently unknown.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $244,277.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Applied immunology (incl. antibody engineering xenotransplantation and t-cell therapies)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Anti-viral drugs and attenuated flavivirus vaccines | Dengue, Japanese encephalitis, yellow fever | Infectious favivirus cDNA clones | arthropod-transmitted diseases | flavivirus attenuation by site-directed mutatagenisis | flavivirus replication | flaviviruses | structure/ function of nonstructural flavivirus proteins | structure/function of UTRs of the flavivirus RNA genome

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