Novel cellular trafficking mechanisms for the drug influx transporter, human Organic Anion Transporting Polypeptide 1A2 (OATP1A2)

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1025101

Funding Status
Closed

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Funded Activity Summary

Human organic anion transporting polypeptides (OATPs) are membrane proteins that regulate the cellular uptake of endogenous and exogenous substances including anti-cancer drugs. OATPs strongly determine whether such drugs enter the tissues where they are required to exert their effects. This project will study novel mechanisms that we have recently identified that determine the orientation of transporters in the cells. These processes can be impaired by a common pharmacogenetic variant in individuals.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $337,614.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pharmacogenomics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

drug absorption | drug clearance | drug therapy | pharmacogenomics | transporters

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