The role of Rnpc3 in U12-type mRNA splicing, gene expression and cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1024878

Funding Status
Closed

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Funded Activity Summary

The zebrafish is a small tropical fish that is an alternative model to mice for genetic studies. We have used zebrafish to discover genes that are essential for the rapid development of the intestine in the belief that these genes are also essential for tumour growth. We will test whether the loss of RNPC3 (the human version of one of our genes), which is required for the production of a small number of proteins that can suppress the development of cancer, plays a hitherto unappreciated causal role in the development of colon tumours.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $593,794.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental Genetics (incl. Sex Determination)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

RNA processing | cancer genetics | colon cancer mechanisms | developmental genetics | gene discovery | gene expression | intestine | mouse models | splicing | zebrafish

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