Membrane trafficking of the ?-secretase, BACE1, and the generation of Alzheimer's disease A? amyloid peptides

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1024561

Funding Status
Closed

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Funded Activity Summary

Alzheimer’s disease results from the production of toxic neuropeptides by the action of an enzyme called BACE. The generation of toxic peptides requires the movement or trafficking of BACE between different cell compartments. This research will reveal the molecular machinery of the BACE transport pathway. This new knowledge will provide a strategy to develop drugs to inhibit BACE activity and the production of the toxic peptide, which would be of significant benefit to patients and families.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $465,704.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Trafficking

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

amyloid precursor protein | endocytosis | endosomes | membrane biology | membrane transport | protein trafficking

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