Astrocytes, mutant TDP-43 and non-cell autonomous injury of motoneurons

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1023780

Funding Status
Closed

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Funded Activity Summary

Motor neuron disease (MND) leads to death of nerve cells, paralysis and death. There is no cure. Mutations in the protein TDP43 cause MND. In this study we will investigate the underlying mechanisms of which these mutations cause disease. We will also investigate how these mutations affect astrocytes, a cell type that maintains normal function and survival of nerve cells and determine if the mutations affect the important interactions that normally takes place between these cell types.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $626,492.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurology and Neuromuscular Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

astrocytes | excitotoxicity | glutamate | inflammation | kinase inhibitors | motor neuron disease (MND) | oxidative stress | protein aggregation | proteomics | signalling

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