Defective toll-like receptor 7 signalling in plasmacytoid dendritic cells underlies the inception of virus-associated asthma

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1023756

Funding Status
Closed

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Funded Activity Summary

In genetically susceptible individuals, respiratory virus infections are a risk factor for asthma inception and are the most common cause of acute exacerbations. Using a clinically relevant mouse model of disease, this study will investigate whether the altered expression of toll-like receptor 7, a host protein that senses viral invasion, causes the host to mount an inappropriate pro-allergic immune response to the virus.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $552,301.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Allergy

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Toll-like receptors | asthma | asthma exacerbation | lung disease | virus detection

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