Aurora kinase: molecular, cellular and functional studies deciphering its role in stroke injury

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1023646

Funding Status
Closed

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Funded Activity Summary

In stroke patients, oxygen deprivation indirectly induces massive nerve cell death by activating an enzyme called aurora kinase A (AURKA). We aim at unravelling (i) how AURKA is activated by oxygen deprivation, (ii) where the activated AURKA is localised in cells, and (iii) how the activated AURKA induces nerve cell death.The study will benefit development of therapeutic strategies to protect against brain damage in stroke since this is novel and different target for drug targeting.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $580,993.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Basic Pharmacology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cell cycle | cerebral ischaemia | excitotoxicity | gene silencing | glutamate receptors | kinase inhibitors | neuronal cell death | neuroprotection | signalling pathways | stroke

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