Generation and persistence of effective T cell immunity towards seasonal and pandemic influenza viruses

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1023294

Funding Status
Closed

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Funded Activity Summary

Introduction of a new influenza strain into human circulation leads to a rapid global spread of the virus (e.g. H1N1 2009 pandemic) due to minimal antibody immunity. Established T cell immunity towards conserved viral regions promotes rapid recovery. However, it is unclear what determines the effective T cell immunity towards influenza. We will define the optimal human T cell populations, with the ultimate goal of improving vaccine design so it protects against seasonal and pandemic strains.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2016

Funding Scheme: Career Development Fellowships

Funding Amount: $451,716.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Infectious Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

T cell immunity | ageing population | cytotoxic T lymphocytes (CTL) | escape mutants | influenza virus | viral immunology

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