Defining the contribution of skin gamma delta T cells to cutaneous immunosurveillance, immunity and disease after HSV infection.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1023250

Funding Status
Closed

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Funded Activity Summary

Herpes simplex virus (HSV) causes genital herpes and encephalitis. Disease is severe in the immunocompromised and the newborn. HSV enters through breaks in the skin or mucosa, where it first encounters gamma delta T cells. We have recently made the key finding that HSV can infect gamma delta T-cells shortly after inoculation. Here we will study how they contribute to the immune response when a virus enters the skin in mice and human tissues. This may lead development of new topical antiviral vaccines.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $601,386.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Virology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Herpes simplex virus (HSV) | infectious diseases | medical virology | skin infections | viral infection

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