The contribution of subunit interfaces to receptor activation in ligand gated ion channels

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1023202

Funding Status
Closed

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Funded Activity Summary

This project seeks to provide insights into new mechanisms that could be used to enhance or inhibit neuronal signalling. The family of pentameric neurotransmitter receptors that are key components in the process of neuronal signalling and are the target of this study. It will investigate the molecular motions that occur when the receptor shifts from the resting state to the activated state in the presence of neurotransmitter. This critical to understanding the normal function of these receptors in the brain and how they can be modulated.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $309,070.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurosciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

electrophysiology | glycine receptors | ligand-gated ion channels | molecular modelling | molecular neuroscience | structure-function

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