Development of functional liver tissue engineered from murine hepatocyte or liver progenitor cell spheroids to correct liver disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1023187

Funding Status
Closed

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Funded Activity Summary

Many patients suffering from severe liver disease require a liver transplant, but due to a shortage of liver donors, many die prior to liver transplantation. This study investigates novel methods of growing liver tissue from mature liver cells called hepatocytes, or, liver stem cells implanted in a plastic chamber in mice with acute and chronic liver disease. It is anticipated that new liver tissue will grow in the chamber, the mice will be cured, and that this technique can be translated to humans with liver disease.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $459,482.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Regenerative Medicine (incl. Stem Cells and Tissue Engineering)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

acute liver injury | capillary growth | cell transplantation | liver regeneration | metabolic disease | surgery | tissue engineering

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