Defining the Myb-p300 dependent transcriptional program in myeloid leukaemia

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1023179

Funding Status
Closed

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Funded Activity Summary

MYB is a “cancer gene” which turns other genes on or off. MYB is needed by leukaemia cells but also for normal blood cell formation. We have found that interaction between the MYB protein and a protein called p300 is more critical for growth of leukaemia cells than for normal cells. Here we aim to identify a set of MYB/p300 co-regulated genes that are needed by leukaemia cells for the continued growth or survival. Some of these genes may be targets for developing new leukaemia drugs.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $603,632.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematological Tumours

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA sequencing | acute myeloid leukaemia (AML) | gene expression | leukaemogenesis | microrna | oncogenes | transcriptional regulation

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