Investigation of cellular abnormalities and synapse formation in DOCK8 immunodeficiency

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1022922

Funding Status
Closed

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Funded Activity Summary

Why do some people get allergies? Or serious infections? To investigate this we will study mice and humans with a mutation in the DOCK8 gene. People with mutations in the DOCK8 gene get Hyper-IgE Syndrome and develop severe viral infections of the skin as well as allergic disease. By investigating how DOCK8 works in the cells of the immune system, we hope to understand why these infections and allergies occur and find out why these problems can also happen in those without this specific genetic defect.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $318,284.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

GTPase | allergy | genomics | germinal centre | immune dysfunction | immunodeficiency | immunoglobulin E (IgE) | signalling pathways | synapse formation

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