Inhibitors of Inducible Nitric Oxide Synthase (iNOS) Regulation as a Basis for Novel Anti-Infective Agents

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1022693

Funding Status
Closed

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Funded Activity Summary

The human enzyme iNOS generates reactive nitrogen species that are required for the intracellular killing of pathogens such as bacteria and parasites. Recently, we showed that the SPSB proteins are key regulators of this important enzyme, and that interfering with this regulation enhanced the anti-microbial actions of iNOS. This project will develop small molecule inhibitors of the SPSB-iNOS interaction for use as novel anti-infective agents in humans.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $643,735.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

X-ray crystallography | bacterial infection | inhibitor design | interaction | medicinal chemistry | nitric oxide synthase (NOS) | nuclear magnetic resonance (NMR) | structure-based drug design

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