Zinc: the molecular basis of it�s toxicity to Gram-positive pathogens and it�s exploitation by the innate immune response

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1022240

Funding Status
Closed

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Funded Activity Summary

Zinc in excess is toxic to bacteria, and the release of zinc is an important part of the immune response. Dietary zinc deficiency leads to increased susceptibility to pathogenic bacteria. How zinc affords protection has remained a mystery. We have identified a novel mechanism in 2 priority human pathogens by which zinc competes for the essential metal ion manganese. We will elucidate the molecular details of this mechanism and how it is harnessed by the immune system.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: NHMRC Project Grants

Funding Amount: $588,398.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Bacteriology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Staphylococcus aureus | Streptococcus pneumoniae | infectious diseases | manganese | membrane protein | metals | pathogenic bacteria | zinc

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