Role in disease of a novel epigenetic regulator associated with the hypervirulent Neisseria meningitidis clonal complex 41/44

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1021631

Funding Status
Closed

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Funded Activity Summary

Neisseria meningitis is a major cause of meningococcal septicaemia and meningitis worldwide. We have identified a phase variable DNA methyltransferase present in disease isolates, some of which have caused meningococcal epidemics. This methyltransferase is involved in the regulation of proteins involved in infection and disease processes. We will investigate whether this regulation increases the ability of the bacteria to adapt to changing host environments and cause disease.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $403,249.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Bacteriology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA methylation | animal model | epigenetics | gene regulation | host/pathogen interaction | meningococcus | microarray analysis | molecular epidemiology | molecular pathogenesis | vaccines

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