micro RNAs - critical regulators of Treg genes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1021586

Funding Status
Closed

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Funded Activity Summary

Natural Treg are dependent on the transcription factor FOXP3, but the mechanism of action of FOXP3 is only now becoming defined for human Treg. Tregs are critical for a balanced, responsive immune system, and deviation from this balance results in autoimmune diseases or persistence of cancers. In order to intervene to treat these disease it is essential to first know what makes a normal Treg function, and to then compare this with the disease so that faulty genes can be targeted for intervention with new drugs or a cell therapy.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $505,798.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

autoimmune disease | gene regulation | immune regulation | molecular biology | molecular immunology

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