Anthracyclines disrupt Ca2+ signalling in cardiomyocytes: a contribution to cardiac toxicity

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1021342

Funding Status
Closed

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Funded Activity Summary

Anthracyclines are one of the most effective drugs used in chemotherapy, but cause side effects resulting in serious heart problems which can be fatal. The link between anthracycline therapy and the problems they cause in the heart is not fully defined. We will investigate mechanisms leading to these side effects and define specific targets of anthracyclines in the heart. It is hoped this will lead to the design of new drugs which counteract the side effects of anthracycline treatment.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $525,620.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

arrhythmia | calcium binding proteins | calcium channels | calcium homeostasis | calcium signalling | cardiac contraction | cardiac dysfunction | cardiac muscle | ion channels | toxicology

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