A novel role for the IL-2 pathway in type-1-diabetes.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1021324

Funding Status
Closed

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Funded Activity Summary

Genes encoding IL-2 and its receptor are strongly linked to susceptibility to multiple autoimmune diseases, including type-1-diabetes. Despite the importance of this pathway in the immune system, it is not yet understood how the associated genes affect disease. In this study, a novel function for IL-2 expression by dendritic cells in normal self-tolerance is investigated. The impacts of dendritic cell produced IL-2 expression and linkage to autoimmunity will be elucidated in both mouse and man.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $548,548.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Autoimmunity

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

T cell response | antigen presenting cells | autoimmune disease | diabetes mellitus | genetic susceptibility | tolerance

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