How the environment and epigenetics affect the brain disease gene, MAPT.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1021269

Funding Status
Closed

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Funded Activity Summary

Genetic variants in the microtubule associated protein Tau (MAPT) gene are major risk factors for Alzheimer’s disease and Parkinson’s disease. Environmental or lifestyle factors, such as diet and smoking, have crucial roles in changing the risk of developing these diseases. These environmental factors may exert their influence via a mechanism known as "epigenetics". This project aims to determine whether the MAPT gene is susceptible to epigenetic changes by environmental factors, and whether this process will have an impact on these diseases.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2012

Funding Scheme: Project Grants

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Epigenetics (incl. Genome Methylation and Epigenomics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | Parkinson disease | animal model | complex genetic disease | disease mechanisms | disease susceptibility | methylation | molecular genetics | neurodegenerative disorders

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