Prevention of neuron death by targeted gene delivery

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/102106

Funding Status
Closed

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Funded Activity Summary

Neurotrophic factors are potent proteins that have the ability to keep nerves alive. They have therefore been used in clinical trials to treat motor neuron disease, but without success. A major reason for this appears to be the way in which the neurotrophic factors are delivered. Direct injections into the blood stream are a convenient way of getting these large proteins into the bloodstream, but this is not their normal mode of action. These proteins are normally provided by cells adjacent to the nerves. We have designed a system that more closely resembles this physiological mode of action which involves the delivery of neurotrophic factor genes, via the bloodstream, to the affected nerves. Once inside the nerves the factors are produced on site and, following their secretion, act locally and directly on the injured nerves.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Development Grants

Funding Amount: $195,691.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical mycology

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

GDNF | Gene therapy | Motor neurons | Neurodegenerative diseases | Neurotrophic factors | Peripheral nerve | Retrograde transport | Survival

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