Release and action of anterogradely transported BDNF from sensory nerve terminals in the spinal cord

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/102105

Funding Status
Closed

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Funded Activity Summary

Neurotrophic factors are powerful agents found in very low amounts throughout the nervous system. Their role is to keep nerves alive, to assist in connecting nerves together and to help maintain the health of nerves. Usually this is achieved by each factor being bound at the end of the long nerve processes and transported back to the nucleus to regulate the metabolism of the nerve. We have discovered one factor, the protein Brain Derived Neurotrophic Factor or BDNF, in one nerve type which is transported in the opposite direction. The project outlined plans to demonstrate the function of this unique transport by showing how BDNF can be released from nerves to act on neighboring cells.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $204,674.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical mycology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Anterograde transport | BDNF | Neurodegenerative diseases | Neurotrophic factors | Nociception | Peripheral nerve | Sensory neurons | Trk B

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