Physiological function of Nedd4-2 in regulating the epithelial sodium channel and cystic fibrosis transmembrane conductance regulator

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1020755

Funding Status
Closed

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Funded Activity Summary

Optimal transport of sodium and chloride ions is essential for the maintenance of electrolyte balance, blood volume, blood pressure and lung function. We are studying the control of a key sodium channel (the epithelial sodium channel) and a key chloride channel (cystic fibrosis transmembrane conductance regulator) by an enzyme called Nedd4-2. This project will enable us to understand how Nedd4-2 regulates these two ion channels and to study the pathological consequences of the loss of Nedd4-2.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $949,572.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Receptors and Membrane Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cystic fibrosis transmembrane regulator (CFTR) | epithelial transport | sodium channel | sodium transport | ubiquitination

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