Interactions between the ? and ? subunits of the DHPR - a missing link in skeletal muscle excitation-contraction coupling and a role in sarcopenia

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1020589

Funding Status
Closed

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Funded Activity Summary

Calcium signaling is disrupted in muscle diseases, including muscle weakness in the elderly. This is a significant problem as all mobility depends on calcium signaling and its disruption can cause serious disability and death. To alleviate defective calcium signaling, the underlying molecular machinery must be fully understood, yet we have only a broad outline of the processes. We will address this problem to provide a platform for alleviating age-related muscle weakness.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $690,832.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Peripheral Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

calcium homeostasis | calcium release | calcium signalling | dihydropyridine receptor | excitation-contraction coupling | ryanodine receptor (RyR) | sarcopenia | skeletal muscle | skeletal muscle wasting

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