Determining the tumour suppressor function of the MCC gene and its significance to treatment outcomes in colorectal cancer.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1020406

Funding Status
Closed

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Funded Activity Summary

This project analyses the early stages of bowel cancer, where we have discovered a new gene defect. We want to determine how the MCC gene defect promotes tumorigenesis and how it affects treatment outcomes, by studying a novel mouse model of bowel cancer. This will determine which cellular functions are altered following loss of MCC in bowel tumours and if the MCC defect can be exploited to identify patients who would benefit from radiotherapy or specific chemotherapies.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $620,716.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Molecular Targets

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

carcinogenesis | chemotherapy treatment effects | colorectal cancer treatment | pre-clinical studies | radiosensitivity | tumour suppressor gene

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