A novel pathway for the regulation of vascular tone

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1020400

Funding Status
Closed

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Funded Activity Summary

The regulation of blood pressure is complex involving the nervous system, kidneys and local pathways that generate blood vessel relaxing and constricting factors. We recently discovered a novel local pathway that becomes induced during inflammation and generates a relaxing substance from the amino acid tryptophan. The present project will identify the active substance and characterize how it causes blood vessel relaxation and thus contributes to the regulation of blood pressure.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $596,550.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cardiovascular pharmacology | chemistry | drug development | inflammation | kynurenine pathway | metabolism | oxidative stress | vascular dysfunction | vascular function

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