Defining the molecular effectors of gene/environment interaction on mouse heart development

Funding Activity

Website
http://grants.uberresearch.com/501100000925/http://purl.org/au-research/grants/nhmrc/1019776/The-effect-of-hypoxia-on-mouse-heart-formation

Funding Status
Closed

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Funded Activity Summary

One third of all birth defects involve the heart, and are the most common cause of infant death. Some defects are due to genetic factors, but others arise when the pregnant mother is exposed to environmental stress. We will examine how one stress (low oxygen levels) causes abnormal heart formation in the embryo, look at what causes this at a molecular level, and explore if such stress increases the risk of heart defects in families with a history of such abnormalities

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $749,271.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental Genetics (incl. Sex Determination)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Notch signalling pathway | Wnt signalling | developmental biology | embryonic development | fibroblast growth factors (FGF) | gene-environment interaction | genetic susceptibility | heart development | hypoxia | mouse models

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