Memory CD4 T cells that harbour the reservoir of latent HIV infection: their antigen specificity, function and frequency of antigen-drivien reactivation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1017991

Funding Status
Closed

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Funded Activity Summary

Current antiretroviral therapy for HIV-1 infection is able to suppress viral replication, but cannot eradicate it completely. Upon cessation of antiviral therapy, viral recrudescence is prompt, and most likely arises from latent reservoirs of HIV in various cellular compartments. The aim of this research is to characterise which subsets of CD4 T cells that are the target of HIV infection harbour HIV infection, including describing their function and individual target antigen specificities.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: NHMRC Postgraduate Scholarships

Funding Amount: $133,351.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

T cell memory | antiretroviral therapy | flow cytometry | human immunodeficiency virus (HIV) | latency | viral persistence

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