The Role of Redox Regulation in Controlling the Oncogenic Function of Eph Receptors

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1017654

Funding Status
Closed

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Funded Activity Summary

Reactive oxygen species (ROS) produced in cancers activate cell surface receptor signalling pathways that drive cancer progression. I will study links between ROS and receptor signalling in cancer cells, and inhibit signalling with ROS scavengers delivered in nanoparticles, targeted to receptor complexes with specific antibodies. These will include antibodies we raised against ADAM10, a protease associated with multiple receptor signalling pathways, to simultaneously inhibit these pathways.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: Postgraduate Scholarships

Funding Amount: $71,766.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Eph receptors | cancer cell biology | cancer metastasis | cancer treatment | inhibitors | reactive oxygen species (ROS) | receptor tyrosine kinase (RTK)

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