Do the mitochondrial sirtuin enzymes, SIRT3 and SIRT5, affect insulin action in skeletal muscle?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1017534

Funding Status
Closed

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Funded Activity Summary

Metabolic disorders such as obesity, insulin resistance and type 2 diabetes are characterised by inappropriate handling of nutrients. Mitochondria are the primary site for nutrient oxidation in cells. Sirtuins such as SIRT3 and SIRT5 are abundant in mitochondria and may affect mitochondrial function and insulin action in skeletal muscle. Understanding the biochemical pathways involved in energy metabolism in skeletal muscle is crucial in the development of therapies for insulin resistance and type 2 diabetes.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: Postgraduate Scholarships

Funding Amount: $92,314.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

acetylation | diabetes mellitus | insulin resistance | metabolic disease | metabolism | obesity | reactive oxygen species (ROS)

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