Genetic Variants, Phenotypic Spectrum and Breast Cancer Risk Associated with Germline Mutations in PALB2: Identifying Female PALB2 Mutation Carriers at the Time of Diagnosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1017121

Funding Status
Closed

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Funded Activity Summary

Population studies of female breast cancer (BC) show only a small proportion of familial aspects of BC can be explained by current knowledge of its causes. Women carrying PALB2 mutations who also have a strong family history of BC are of increased risk of BC. Our work will further define the risks and devise criteria to identify women most likely to carry PALB2 mutations. This will help prioritize testing, classify PALB2 variants and provide appropriate clinical management to carriers.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2012

Funding Scheme: NHMRC Postgraduate Scholarships

Funding Amount: $45,093.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Genetics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

breast cancer aetiology | cancer epidemiology | diagnostic criteria | early breast cancer | familial cancer | hereditary breast cancer | molecular genetics | pathological diagnosis | risk assessment

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