Development of pthaladyn-based dynamin I-selective inhibitors for treatment of epilepsy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1017063

Funding Status
Closed

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Funded Activity Summary

About 1% of the World�s population suffers from epilepsy; 30% fail to respond to anti-epileptic drugs (AED). Current AED development pathways have changed little in the past 20 years with the majority of current AEDs dampening the release of crucial chemical signals 24/7. Our new drugs, which inhibit a protein called dynamin, are only recruited at the onset of a seizure. Our approach will significantly enhance the day to day lives of those afflicted by epilepsy.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Development Grants

Funding Amount: $564,310.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antiepileptic drugs | drug development | drug toxicity | dynamin | epilepsy | medicinal chemistry | nerve terminals | neurons | synaptic transmission

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