Apoptosis and Stem Cells in Cancer Development and Therapy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1016701

Funding Status
Closed

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Funded Activity Summary

To improve cancer therapy, we are studying two cancer hallmarks: enhanced cell survival and stem cell-like behaviour. As we discovered, cell death is often blocked in cancer cells. Hence, we are attempting to develop drugs that flip the natural ‘cell death switch’. Stem cells are rare cells that generate entire tissues, as we showed for the breast. Certain cancers may be driven by ‘rogue’ stem cells. If so, eradication of these rare cells within the bulk tumour may require novel therapies.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2016

Funding Scheme: Program Grants

Funding Amount: $22,852,198.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Bcl-2 | anticancer drug | apoptosis | autoimmunity | cell death | oncogenesis | stem cells | tumourigenesis

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